Pub. Date : 2012 Jun 1
PMID : 22561209
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells. | Berberine | ataxia telangiectasia mutated | Mus musculus |
| 2 | Pharmacological inhibition of ATM by KU55933, or Chk1 by UCN-01, could efficiently abrogate the G2/M arrest in berberine-treated cells. | Berberine | ataxia telangiectasia mutated | Mus musculus |
| 3 | Abrogation of G2/M arrest by ATM inhibition forced more cells to undergo apoptosis in response to berberine treatment. | Berberine | ataxia telangiectasia mutated | Mus musculus |