Pub. Date : 2012 Jul
PMID : 22552582
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. | Polyphenols | tumor protein p53 | Homo sapiens |
| 2 | In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells. | Polyphenols | tumor protein p53 | Homo sapiens |