Title : Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

Pub. Date : 2012 Jun 14

PMID : 22551018






1 Functional Relationships(s)
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Protein Name
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1 The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKbeta, key features lacking from the initial compounds. Ribose cyclin dependent kinase 1 Homo sapiens