Title : Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.

Pub. Date : 2013 Oct

PMID : 22549898






4 Functional Relationships(s)
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1 Only UA efficiently suppressed the AMF/PGI-induced Huh7 cell migration and MMP-3 secretion. ursolic acid glucose-6-phosphate isomerase Homo sapiens
2 Additionally, UA inhibited the AMF/PGI-mediated protection against TGF-beta-induced apoptosis in Hep3B cells, whereas OA, tangeretin, and nobiletin had no effect. ursolic acid glucose-6-phosphate isomerase Homo sapiens
3 In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI. ursolic acid glucose-6-phosphate isomerase Homo sapiens
4 In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation. ursolic acid glucose-6-phosphate isomerase Homo sapiens