Title : Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells.

Pub. Date : 2012 Jul

PMID : 22547569






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Conversely, proteolysis of 5alpha-dihydrotestosterone (DHT)-bound SHBG was similar for both KLKs and left the steroid binding LG4 domain intact. Dihydrotestosterone sex hormone binding globulin Homo sapiens
2 Conversely, proteolysis of 5alpha-dihydrotestosterone (DHT)-bound SHBG was similar for both KLKs and left the steroid binding LG4 domain intact. Dihydrotestosterone sex hormone binding globulin Homo sapiens
3 Consistent with this, both full-length SHBG and SHBG-LG4 significantly increased DHT-mediated transcriptional activity of the androgen receptor compared with DHT delivered without carrier protein. Dihydrotestosterone sex hormone binding globulin Homo sapiens
4 Consistent with this, both full-length SHBG and SHBG-LG4 significantly increased DHT-mediated transcriptional activity of the androgen receptor compared with DHT delivered without carrier protein. Dihydrotestosterone sex hormone binding globulin Homo sapiens