Title : Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism.

Pub. Date : 2012 Jun 1

PMID : 22546668






1 Functional Relationships(s)
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1 The structure-activity relationships of N-(3-acyloxy-2-benzylpropyl)-N"-4-[(methylsulfonylamino)benzyl] thioureas, which represent simplified RTX-based vanilloids, were investigated by varying the distances between the four principal pharmacophores and assessing binding and antagonistic activity on rTRPV1. resiniferatoxin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus