Title : Mitotane exhibits dual effects on steroidogenic enzymes gene transcription under basal and cAMP-stimulating microenvironments in NCI-H295 cells.

Pub. Date : 2012 Aug 16

PMID : 22546480






1 Functional Relationships(s)
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1 Mitotane (40muM) almost completely neutralized this positive effect and returned 8-Br-cAMP-induced StAR, CYP11A1, CYP17 and CYP21 mRNA to control levels. 8-Bromo Cyclic Adenosine Monophosphate cytochrome P450 family 17 subfamily A member 1 Homo sapiens