Pub. Date : 2012 Feb
PMID : 22512091
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Bortezomib decreased IkappaB degradation, decreased NF-kappaB and NF-kappaB p65 activity, reduced P-gp/mdr1 mRNA expression, and increased the intracellular DNR concentration in K562/DNR cells in vitro. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Bortezomib decreased IkappaB degradation, decreased NF-kappaB and NF-kappaB p65 activity, reduced P-gp/mdr1 mRNA expression, and increased the intracellular DNR concentration in K562/DNR cells in vitro. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The bortezomib reversed leukemic multi-drug resistance in a dose-dependent manner as the result of decreasing IkappaB degradation, thus preventing the translocation of NF-kappaB into the nucleus and leading the down-regulation of mdr1 and a reduction in P-gp expression. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The bortezomib reversed leukemic multi-drug resistance in a dose-dependent manner as the result of decreasing IkappaB degradation, thus preventing the translocation of NF-kappaB into the nucleus and leading the down-regulation of mdr1 and a reduction in P-gp expression. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |