Pub. Date : 2012 Apr 13
PMID : 22500608
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. | Serotonin | catechol-O-methyltransferase | Homo sapiens |
| 2 | Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). | Serotonin | catechol-O-methyltransferase | Homo sapiens |
| 3 | Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). | Serotonin | catechol-O-methyltransferase | Homo sapiens |
| 4 | Binding of serotonin to the catalytic site inhibits the access of SAM, thus preventing methylation of COMT substrates. | Serotonin | catechol-O-methyltransferase | Homo sapiens |
| 5 | Our results suggest that inhibition of COMT via serotonin binding contributes to pain hypersensitivity, providing additional strategies for the treatment of clinical pain conditions. | Serotonin | catechol-O-methyltransferase | Homo sapiens |