Title : Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner.

Pub. Date : 2012 Apr 17

PMID : 22497828






1 Functional Relationships(s)
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Protein Name
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1 A protein kinase C (PKC)-alpha/beta1 inhibitor or PKC-beta1 small interfering RNA and an AT1 blocker prevented alcohol-induced activation of NOX, and the AT1 blocker losartan significantly inhibited the expression of PKC-beta1, indicating that alcohol-induced activation of NOX is mediated by PKC-beta1 via AT1. Alcohols protein kinase C, alpha Mus musculus