Title : Physiological concentrations of genistein and 17β-estradiol inhibit MDA-MB-231 breast cancer cell growth by increasing BAX/BCL-2 and reducing pERK1/2.

Pub. Date : 2012 Apr

PMID : 22493348






2 Functional Relationships(s)
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1 Physiological concentrations of genistein and 17beta-estradiol inhibit MDA-MB-231 breast cancer cell growth by increasing BAX/BCL-2 and reducing pERK1/2. Estradiol BCL2 apoptosis regulator Homo sapiens
2 RESULTS: Compared to the control, 1 muM genistein plus 1 nM 17beta-estradiol significantly increased apoptosis, and the BAX/BCL-2 ratio, with a concomitant decrease in ERK1/2 phosphorylation. Estradiol BCL2 apoptosis regulator Homo sapiens