Title : [The effect of cell killing by ABT-737 synergized with docetaxel in human prostate cancer PC-3 cells].

Pub. Date : 2012 Feb 1

PMID : 22490358






1 Functional Relationships(s)
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1 CONCLUSIONS: The combination of ABT-737 with docetaxel can synergistically inhibit the proliferation of PC-3 cells through inducing apoptosis, which may be associated with cell cycle arrest, down-regulation of Bcl-2, Bcl-xL and Mcl-1 expression and activation of caspase-3. Docetaxel MCL1 apoptosis regulator, BCL2 family member Homo sapiens