Pub. Date : 2012 Jun
PMID : 22489671
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine induced ER stress, as evidenced by survival molecules, such as phosphorylated protein kinase-like ER-resident kinase, phosphorylated eukaryotic initiation factor-2alpha and glucose-regulated protein-78, and apoptotic molecules, such as CAAT/enhancer binding protein homologous protein (CHOP). | Nicotine | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Inhibition of ER stress by salubrinal and transfection of CHOP small interfering RNA attenuated the nicotine-induced cell death, ECM degradation and production of MMPs. | Nicotine | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Salubrinal and CHOP small interfering RNA inhibited the effects of nicotine on the activation of Akt, JNK and nuclear factor-kappaB. | Nicotine | DNA damage inducible transcript 3 | Homo sapiens |