Title : The endothelin A receptor and epidermal growth factor receptor signaling converge on β-catenin to promote ovarian cancer metastasis.

Pub. Date : 2012 Oct 15

PMID : 22480520

1 Functional Relationships(s)
Compound Name
Protein Name
1 KEY FINDINGS: In EOC cell lines, ET-1 induced Src-dependent EGFR transactivation, causing tyrosine (Y) phosphorylation of beta-catenin at the residue Y654, its dissociation from E-cadherin complexes and the accumulation as an active form. Tyrosine catenin beta 1 Homo sapiens