Pub. Date : 2012
PMID : 22470521
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since GD3S is the key enzyme converting a- to b-series gangliosides, it therefore plays a major role in controlling the levels of major brain gangliosides. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |
| 2 | Since GD3S is the key enzyme converting a- to b-series gangliosides, it therefore plays a major role in controlling the levels of major brain gangliosides. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |
| 3 | The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |
| 4 | The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |
| 5 | The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |
| 6 | GM3 decreased, whereas the ganglioside GD3, the GD3S product, increased Abeta production, resulting in a regulatory feedback cycle, directly linking ganglioside metabolism with APP processing and Abeta generation. | Gangliosides | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | Homo sapiens |