Title : Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells.

Pub. Date : 2012 Jul

PMID : 22463588






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We found that treatment of cells with low concentration (5 muM) arsenite attenuated cellular apoptosis upon UVB radiation accompanied with a coinductive effect on COX-2 expression and nuclear factor-kappaB (NFkappaB) transactivation. arsenite nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells. arsenite nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells. arsenite nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 Our results indicated that COX-2 mediated the anti-apoptotic effect of arsenite in UVB radiation through an NFkappaB-dependent pathway. arsenite nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus