Pub. Date : 2012 Aug
PMID : 22459907
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response. | Clopidogrel | coagulation factor II thrombin receptor | Homo sapiens |
| 2 | Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response. | Clopidogrel | coagulation factor II thrombin receptor | Homo sapiens |
| 3 | Thrombin induces platelet aggregation by binding to protease activated receptor-1 (PAR-1), and inhibition of PAR-1 has been evaluated in patients treated with clopidogrel to reduce ischemic events after acute coronary syndromes. | Clopidogrel | coagulation factor II thrombin receptor | Homo sapiens |
| 4 | Residual PAR-1 mediated platelet aggregation may be dependent on extent of clopidogrel response. | Clopidogrel | coagulation factor II thrombin receptor | Homo sapiens |
| 5 | Addition of PAR-1 antiplatelet drugs may be most effective in patients with reduced clopidogrel response and high residual TRAP mediated platelet aggregation. | Clopidogrel | coagulation factor II thrombin receptor | Homo sapiens |