Title : Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

Pub. Date : 2012 Jun

PMID : 22449798






2 Functional Relationships(s)
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Protein Name
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1 Mallory-Denk bodies (MDBs) appeared in krt18-/- mice already at an early stage of intoxication in contrast to krt8-/- mice that did not display MDB formation when fed with DDC. mdb keratin 18 Mus musculus
2 Chronically DDC-intoxicated krt18-/- and wt mice showed a similarly increased degree of steatohepatitis with hepatocyte ballooning and MDB formation. mdb keratin 18 Mus musculus