Title : Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver.

Pub. Date : 2012 Jun

PMID : 22446520






1 Functional Relationships(s)
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1 In the inhibition assay, the flutamide hydrolase activities at a flutamide concentration of 5 muM in human liver and jejunum microsomes were strongly inhibited by a selective CES2 inhibitor, 10 muM loperamide, with the residual activities of 22.9 +- 3.5 and 18.6 +- 0.7%, respectively. Loperamide carboxylesterase 2 Homo sapiens