Pub. Date : 2012 Mar 22
PMID : 22439811
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acute morphine activates satellite glial cells and up-regulates IL-1beta in dorsal root ganglia in mice via matrix metalloprotease-9. | Morphine | interleukin 1 beta | Mus musculus |
| 2 | We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1beta in dorsal root ganglia (DRGs), and further investigated the involvement of MMP-9 in these opioid-induced peripheral changes. | Morphine | interleukin 1 beta | Mus musculus |
| 3 | The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs. | Morphine | interleukin 1 beta | Mus musculus |
| 4 | The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs. | Morphine | interleukin 1 beta | Mus musculus |
| 5 | The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs. | Morphine | interleukin 1 beta | Mus musculus |
| 6 | The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs. | Morphine | interleukin 1 beta | Mus musculus |
| 7 | Importantly, morphine-induced DRG up-regulation of GFAP expression and IL-1beta activation was abolished after Mmp9 deletion or naloxone pre-treatment. | Morphine | interleukin 1 beta | Mus musculus |
| 8 | Finally, intrathecal injections of IL-1beta-selective siRNA not only reduced DRG IL-1beta expression but also prolonged acute morphine-induced analgesia. | Morphine | interleukin 1 beta | Mus musculus |
| 9 | CONCLUSIONS: Acute morphine induces opioid receptors- and MMP-9-dependent up-regulation of GFAP expression and IL-1beta activation in SGCs of DRGs. | Morphine | interleukin 1 beta | Mus musculus |