PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22439811-0	2012	Acute morphine activates satellite glial cells and up-regulates IL-1beta in dorsal root ganglia in mice via matrix metalloprotease-9.	Morphine	6-14	interleukin 1 beta	Mus musculus	64-72	
22439811-4	2012	We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1beta in dorsal root ganglia (DRGs), and further investigated the involvement of MMP-9 in these opioid-induced peripheral changes.	Morphine	18-26	interleukin 1 beta	Mus musculus	99-107	
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	10-18	interleukin 1 beta	Mus musculus	137-145	
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	10-18	interleukin 1 beta	Mus musculus	175-183	
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	103-111	interleukin 1 beta	Mus musculus	137-145	
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	103-111	interleukin 1 beta	Mus musculus	175-183	
22439811-9	2012	Importantly, morphine-induced DRG up-regulation of GFAP expression and IL-1beta activation was abolished after Mmp9 deletion or naloxone pre-treatment.	Morphine	13-21	interleukin 1 beta	Mus musculus	71-79	
22439811-10	2012	Finally, intrathecal injections of IL-1beta-selective siRNA not only reduced DRG IL-1beta expression but also prolonged acute morphine-induced analgesia.	Morphine	126-134	interleukin 1 beta	Mus musculus	35-43	
22439811-11	2012	CONCLUSIONS: Acute morphine induces opioid receptors- and MMP-9-dependent up-regulation of GFAP expression and IL-1beta activation in SGCs of DRGs.	Morphine	19-27	interleukin 1 beta	Mus musculus	111-119