Title : Simultaneous determination of fluoxetine and norfluoxetine enantiomers using isotope discrimination mass spectroscopy solution method and its application in the CYP2C9-mediated stereoselective interactions.

Pub. Date : 2012 May 4

PMID : 22436668






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The half-maximal inhibitory concentration values between R-FLX and S-FLX catalyzed by CYP2C9*1 and CYP2C9*2 were determined in this study. r-flx cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 The half-maximal inhibitory concentration values between R-FLX and S-FLX catalyzed by CYP2C9*1 and CYP2C9*2 were determined in this study. r-flx cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 The inhibitory effects of R- to S-FLX were stronger than those of S- to R-FLX in both CYP2C9*1 and CYP2C9*2. r-flx cytochrome P450 family 2 subfamily C member 9 Homo sapiens
4 The inhibitory effects of R- to S-FLX were stronger than those of S- to R-FLX in both CYP2C9*1 and CYP2C9*2. r-flx cytochrome P450 family 2 subfamily C member 9 Homo sapiens