Title : Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma.

Pub. Date : 2012

PMID : 22428038






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1 CONCLUSIONS: Activation of PI3K/AKT and MAPK pathway through a PDGFRbeta-dependent feedback loop compromises the anti-tumor activity of rapamycin in HCC, and blockade of this feedback loop by sorafenib is an attractive approach to improve the anti-tumor effect of rapamycin, particularly in preventing or treating HCC recurrence after liver transplantation. Sorafenib AKT serine/threonine kinase 1 Rattus norvegicus