Pub. Date : 2012 May
PMID : 22419721
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: Our objective was to determine how PR-A and PR-B regulate progesterone action in human myometrial cells and specifically the expression of genes encoding contraction-associated proteins and proinflammatory mediators. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 2 | DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 3 | DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 4 | DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 5 | RESULTS: PR-A and PR-B were each transcriptionally active in response to progesterone and affected the expression of distinct gene cohorts. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our data suggest that during most of human pregnancy, when myometrial cells are PR-B dominant, progesterone promotes myometrial quiescence through PR-B-mediated antiinflammatory actions. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |
| 7 | CONCLUSIONS: Our data suggest that during most of human pregnancy, when myometrial cells are PR-B dominant, progesterone promotes myometrial quiescence through PR-B-mediated antiinflammatory actions. | Progesterone | RB transcriptional corepressor 1 | Homo sapiens |