Title : Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents.

Pub. Date : 2012 Apr 15

PMID : 22414612






2 Functional Relationships(s)
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1 The binding mode of 1 from docking simulation in the EGFR active site revealed that the urea motif formed hydrogen bonding with Lys745, Thr854 and Asp855 in hydrophobic pocket of EGFR. Hydrogen epidermal growth factor receptor Homo sapiens
2 The binding mode of 1 from docking simulation in the EGFR active site revealed that the urea motif formed hydrogen bonding with Lys745, Thr854 and Asp855 in hydrophobic pocket of EGFR. Hydrogen epidermal growth factor receptor Homo sapiens