Title : The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation.

Pub. Date : 2012 May 4

PMID : 22411987






5 Functional Relationships(s)
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1 Evidence is provided that the membrane-proximal lysines at positions 144 and 237, located in the Cx43 intracellular loop and C-terminal tail, respectively, act as SUMO conjugation sites. Lysine gap junction protein alpha 1 Homo sapiens
2 Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels. Lysine gap junction protein alpha 1 Homo sapiens
3 Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels. Lysine gap junction protein alpha 1 Homo sapiens
4 Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels. Lysine gap junction protein alpha 1 Homo sapiens
5 Mutations of lysine 144 or lysine 237 resulted in reduced Cx43 SUMOylation and reduced Cx43 protein and gap junction levels. Lysine gap junction protein alpha 1 Homo sapiens