Title : Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.

Pub. Date : 2012 Jun

PMID : 22406476






5 Functional Relationships(s)
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1 We investigated whether aspirin affects adenosine monophosphate-activated protein kinase (AMPK) and mTOR signaling in CRC cells. Aspirin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 We investigated whether aspirin affects adenosine monophosphate-activated protein kinase (AMPK) and mTOR signaling in CRC cells. Aspirin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 Aspirin changed nucleotide ratios and activated AMPK in CRC cells. Aspirin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
4 Aspirin and metformin (an activator of AMPK) increased inhibition of mTOR and Akt, as well as autophagy in CRC cells. Aspirin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
5 CONCLUSIONS: Aspirin is an inhibitor of mTOR and an activator of AMPK, targeting regulators of intracellular energy homeostasis and metabolism. Aspirin protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens