Pub. Date : 2012 Mar 30
PMID : 22405824
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. | Desipramine | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | DMI acted as a signaling potentiator, selectively enhancing NE-induced alpha(2A)AR-mediated ERK1/2 MAPK signaling. | Desipramine | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | DMI acted as a signaling potentiator, selectively enhancing NE-induced alpha(2A)AR-mediated ERK1/2 MAPK signaling. | Desipramine | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | DMI in a physiologically relevant ratio with NE effectively turned on ERK1/2 signaling that is lacking in response to physiological NE alone. | Desipramine | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | Further, the DMI-induced ERK1/2 potentiation relied on heterotrimeric G(i/o) proteins and was arrestin-independent. | Desipramine | mitogen-activated protein kinase 3 | Homo sapiens |