Pub. Date : 2012 Mar
PMID : 22399605
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SN-38 overcomes chemoresistance of colorectal cancer cells induced by hypoxia, through HIF1alpha. | Irinotecan | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | This effect was dependent on the significant inhibition of the accumulation of HIF-1alpha in cancer cells cultured under hypoxia by SN-38. | Irinotecan | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | CONCLUSION: SN-38, through inhibition of HIF-1alpha can overcome chemoresistance under hypoxic conditions of colon cancer cells. | Irinotecan | hypoxia inducible factor 1 subunit alpha | Homo sapiens |