Title : 5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis.

Pub. Date : 2012 Jul

PMID : 22398368






2 Functional Relationships(s)
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1 Additionally, suppression of DPP4 expression with siRNA induced elevated protein levels of FDPS and FDFT1, and increased cholesterol biosynthesis in WM-266-4 cells. Cholesterol dipeptidyl peptidase 4 Homo sapiens
2 Together, the results from the present study revealed, for the first time, that 5-Aza-CdR exerts its cytotoxic effects in leukemia and melanoma cells through epigenetic reactivation of DPP4 gene and the resultant inhibition of cholesterol biosynthesis in these cells. Cholesterol dipeptidyl peptidase 4 Homo sapiens