Title : Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

Pub. Date : 2012 May 4

PMID : 22396533






3 Functional Relationships(s)
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1 Recently, we showed that mitochondrion-targeted CYP2E1 augments alcohol-mediated toxicity, causing an increase in reactive oxygen species production and oxidative stress. Alcohols cytochrome P450 family 2 subfamily E member 1 Homo sapiens
2 COS-7 and Hep G2 cell lines expressing predominantly mitochondrion-targeted (Mt(++)) CYP2E1 and livers from alcohol-treated rats showed loss of CcO activity and increased protein carbonylation, which was accompanied by a decline in the steady state levels of subunits I, IVI1, and Vb of the CcO complex. Alcohols cytochrome P450 family 2 subfamily E member 1 Homo sapiens
3 Our results suggest that damage to CcO and dissociation of respirosome complexes are critical factors in alcohol-induced toxicity, which is augmented by mitochondrion-targeted CYP2E1. Alcohols cytochrome P450 family 2 subfamily E member 1 Homo sapiens