Title : Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle.

Pub. Date : 2012 May

PMID : 22396207






6 Functional Relationships(s)
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1 CR increased the protein level of AMPK-alpha2 and phosphorylation of AMPK-alpha2. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus
2 CR increased the protein level of AMPK-alpha2 and phosphorylation of AMPK-alpha2. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus
3 In WT and AMPK-alpha2(-/-) mice, CR induced comparable changes of body weight, fat pad weight, serum triglycerides, serum nonesterified fatty acids, and serum leptin levels. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus
4 Moreover, CR-induced improvements of whole-body insulin sensitivity (evidenced by glucose tolerance test/insulin tolerance test assays) and glucose uptake in skeletal muscle tissues were abolished in AMPK-alpha2(-/-) mice. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus
5 CR serum increased stability of AMPK-alpha2 protein via inhibiting the X chromosome-linked ubiquitin-specific protease 9-mediated ubiquitylation of AMPK-alpha2. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus
6 CR serum increased stability of AMPK-alpha2 protein via inhibiting the X chromosome-linked ubiquitin-specific protease 9-mediated ubiquitylation of AMPK-alpha2. Chromium protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus