Protein Name protein kinase, AMP-activated, alpha 2 catalytic subunit
Organism Mus musculus
Gene ID 108079
Gene Symbol

Prkaa2

UniProt Q8BRK8 (AAPK2_MOUSE)
Relationships Total Number of functionally related compound(s) : 126
Total Number of Articles : 126
Description

protein kinase, AMP-activated, alpha 2 catalytic subunit

Gene Summary

Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; negative regulation of macromolecule metabolic process; and regulation of autophagy. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is active in cytosol. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • 5'-AMP-activated protein kinase catalytic subunit alpha-2
  • ACACA kinase
  • AMPK subunit alpha-2
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Properties