Title : Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.

Pub. Date : 2012 Apr 18

PMID : 22394239






1 Functional Relationships(s)
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1 Instead of the in situ protein-templated azide-alkyne cycloaddition reaction occurring at a localized, sequestered enzyme active center as previously shown, we demonstrate that the in situ reaction can take place at the subunit interfaces of an oligomeric protein and can thus be used as a tool for identifying novel candidate nAChR ligands. Azides cholinergic receptor nicotinic alpha 4 subunit Homo sapiens