Title : NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis.

Pub. Date : 2012

PMID : 22393394






2 Functional Relationships(s)
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1 CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation. Reactive Oxygen Species interleukin 18 Homo sapiens
2 CONCLUSION/SIGNIFICANCE: Our results identify a mechanism mediated by Reactive Oxygen Species (ROS) production and potassium efflux as the two danger signals that link JEV infection to caspase-1 activation resulting in subsequent IL-1beta and IL-18 maturation. Reactive Oxygen Species interleukin 18 Homo sapiens