Title : A LC-MS/MS method to evaluate the hepatic uptake of the liver-specific magnetic resonance imaging contrast agent gadoxetate (Gd-EOB-DTPA) in vitro and in humans.

Pub. Date : 2012 Apr 1

PMID : 22391331






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B1 Homo sapiens
2 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. gadolinium ethoxybenzyl DTPA solute carrier organic anion transporter family member 1B1 Homo sapiens