Pub. Date : 2012 May
PMID : 22387748
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | We have previously demonstrated that low concentrations of arsenite inhibit poly(ADP-ribose) polymerase (PARP)-1, thus interfering with DNA repair process triggered by UV radiation. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Notably, knockdown of PARP-1 with small interfering RNA completely abolished the antagonism of arsenite. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Together, these results suggest that low concentration of arsenite reduces UV-induced apoptosis via inhibiting PARP-1, thus promoting the survival of cells with unrepaired DNA lesions, which may be an important mechanism underlying arsenic cocarcinogenic action. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |