Pub. Date : 2012 Jul
PMID : 22387464
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast to their similar in vitro properties, transcriptional activation of oct4 by these distinct dTALEs varied up to 25-fold. | dtales | POU class 5 homeobox 1 | Homo sapiens |
| 2 | While dTALEs efficiently upregulated transcription of the active oct4 promoter in embryonic stem cells (ESCs) they failed to activate the silenced oct4 promoter in ESC-derived neural stem cells (NSCs), indicating that as for endogenous transcription factors also dTALE activity is limited by repressive epigenetic mechanisms. | dtales | POU class 5 homeobox 1 | Homo sapiens |
| 3 | Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only. | dtales | POU class 5 homeobox 1 | Homo sapiens |
| 4 | Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only. | dtales | POU class 5 homeobox 1 | Homo sapiens |