Title : Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli.

Pub. Date : 2012 May 1

PMID : 22387174






3 Functional Relationships(s)
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1 Thus, the aim of the present study was to re-evaluate the impact of the COMT val158met variant on neural activation correlates of emotional face processing in a sample of healthy probands. val158met catechol-O-methyltransferase Homo sapiens
2 The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. val158met catechol-O-methyltransferase Homo sapiens
3 The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. val158met catechol-O-methyltransferase Homo sapiens