Pub. Date : 2012 Apr
PMID : 22386763
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of Val16Ala SOD2 polymorphism on the in-vitro effect of clomiphene citrate in oxidative metabolism. | Clomiphene | superoxide dismutase 2 | Homo sapiens |
| 2 | The results suggest that clomiphene citrate exhibits antioxidant activity similar to that observed with other selective oestrogen receptor modulators, and the intensity of the effect appears to be SOD2 polymorphism dependent. | Clomiphene | superoxide dismutase 2 | Homo sapiens |
| 3 | Significant differences of the clomiphene citrate antioxidant effect on PBMC with different Val16Ala SOD genotypes were observed in this study. | Clomiphene | superoxide dismutase 2 | Homo sapiens |
| 4 | Based on these results, we could speculate that alterations in SOD2 activity caused by the Val16Ala polymorphism can result in differential responses to drugs such as clomiphene citrate. | Clomiphene | superoxide dismutase 2 | Homo sapiens |