Title : Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.

Pub. Date : 2012 Apr 1

PMID : 22386564






1 Functional Relationships(s)
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1 The moderate and non-selective aromatase inhibitory activity of resveratrol (1) was improved about 100-fold by replacement of the ethylenic bridge with a thiadiazole and the phenyl rings with pyridines (e.g., compound 3). Pyridines cytochrome P450 family 19 subfamily A member 1 Homo sapiens