Title : Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Pub. Date : 2012 Apr

PMID : 22386260






1 Functional Relationships(s)
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1 When their ability to inhibit Pim kinase activities were evaluated in in vitro assays, we observed that this nitrogen atom can be substituted without loss of Pim-1 and Pim-3 inhibitory potencies. Nitrogen Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens