Title : Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways.

Pub. Date : 2012 Jun

PMID : 22383427






1 Functional Relationships(s)
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1 (3)H-thymidine incorporation assays revealed that sorafenib causes a dose-dependent inhibition of proliferation of all cell lines associated with downregulation of cyclin-dependent kinase 2 and cyclin D1 expression. Sorafenib cyclin dependent kinase 2 Homo sapiens