Title : Effects of halogenation on tyrosine phosphorylation and peptide binding to the SRC homology 2 domain of lymphocyte-specific protein tyrosine kinase.

Pub. Date : 2012

PMID : 22382333






2 Functional Relationships(s)
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1 The EGFR- and Lck-mediated phosphorylation was markedly inhibited by tyrosine halogenation. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
2 We also examined the effect of iodination and nitration of tyrosine residues on binding to the SH2 domain of Lck, using a model peptide containing the phosphoTyr-Glu-Glu-Ile motif, which has a high affinity for the SH2 domain. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens