Pub. Date : 2012 Sep 15
PMID : 22360429
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: The aim of the present study was to evaluate the therapeutic effect of the novel neuroprotective multi-target nontoxic, lipophilic, brain permeable monoamine oxidase inhibitor and iron chelating-radical scavenging drug, M30, on the neuropathology and deficits of spatial learning and memory in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (Tg) Alzheimer"s disease (AD) mice. | Iron | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | Here, for the first time, we demonstrated that, when systemically administered to APP/PS1 Tg mice, our novel multifunctional iron chelating/radical scavenging compound, M30, effectively reduced Abeta accumulation and tau phosphorylation, and attenuated memory deficits. | Iron | amyloid beta (A4) precursor protein | Mus musculus |