Title : PI3K signalling: the path to discovery and understanding.

Pub. Date : 2012 Feb 23

PMID : 22358332






1 Functional Relationships(s)
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1 Elucidation of PI3K-dependent networks led to the discovery of the phosphoinositide-binding PH, PX and FYVE domains as conduits of intracellular lipid signalling, the determination of the molecular function of the tumour suppressor PTEN and the identification of AKT and mTOR protein kinases as key regulators of cell growth. Phosphatidylinositols phosphatase and tensin homolog Homo sapiens