Pub. Date : 2012 Jul
PMID : 22357520
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To understand how telmisartan partially activates PPARgamma, we determined the ternary complex structure of PPARgamma, telmisartan, and a coactivator peptide from steroid receptor coactivator-1 at a resolution of 2.18 A. Crystallographic analysis revealed that telmisartan exhibits an unexpected binding mode in which the central benzimidazole ring is engaged in a non-canonical--and suboptimal--hydrogen-bonding network around helix 12 (H12). | benzimidazole | peroxisome proliferator activated receptor gamma | Homo sapiens |