Title : Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway.

Pub. Date : 2012 Jun

PMID : 22349744






2 Functional Relationships(s)
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1 The data also revealed that sevoflurane could decrease the phosphorylation level of p38 MAPK, which is involved in the downregulation of MMP-2, MMP-9, fascin, and ezrin expression, accompanied by a concomitant inhibition of the invasion and migration of A549 cells. Sevoflurane matrix metallopeptidase 2 Homo sapiens
2 CONCLUSION: The anti-invasion effect of sevoflurane on A549 cells was associated with a downregulation of both MMP-2 and MMP-9 expression, while the anti-migration effect was associated with a downregulation of both fascin and ezrin expression. Sevoflurane matrix metallopeptidase 2 Homo sapiens