Title : Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells.

Pub. Date : 2012 Jun

PMID : 22349311






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1 In addition, we demonstrated that the effect of nicotine in upregulation of HIF-1alpha was mediated by Dihydro-beta-erythroidine (DhbetaE)-sensitive nicotine acetylcholine receptors (nAChRs) and required synergistic cooperation of Akt and mitogen-activated protein kinase (MAPK) pathways. Nicotine AKT serine/threonine kinase 1 Homo sapiens