Title : Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells.

Pub. Date : 2012 Jun

PMID : 22349311

1 Functional Relationships(s)
Compound Name
Protein Name
1 In addition, we demonstrated that the effect of nicotine in upregulation of HIF-1alpha was mediated by Dihydro-beta-erythroidine (DhbetaE)-sensitive nicotine acetylcholine receptors (nAChRs) and required synergistic cooperation of Akt and mitogen-activated protein kinase (MAPK) pathways. Nicotine AKT serine/threonine kinase 1 Homo sapiens