PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22349311-6	2012	In addition, we demonstrated that the effect of nicotine in upregulation of HIF-1alpha was mediated by Dihydro-beta-erythroidine (DhbetaE)-sensitive nicotine acetylcholine receptors (nAChRs) and required synergistic cooperation of Akt and mitogen-activated protein kinase (MAPK) pathways.	Nicotine	48-56	AKT serine/threonine kinase 1	Homo sapiens	231-234